Espectro Quinolonas Pdf To Word

Espectro quinolonas pdf to word

ANTIBIOTICOS - QUINOLONAS

Las quinolonas que contienen unaaminopirrolidina tosufloxacino, clinafloxacino parece quepresentan una mayor actividad frente a grampositivos, mientras quelos que tienen una piperazina presentan una mayor actividad frentea gramnegativos 3. En el caso de el trovafloxacino elsubstituyente es una ciclopropilpirrolidina, el cual le otorga unaalta actividad frente a grampositivos El conjunto de todasestas acciones conduce a la muerte bacteriana..

Se han descritouna serie de mecanismos de resistencia que han desarrollado losmicroorganismos frente a las quinolonas.

Laactividad invitro de ellevofloxacino aparece reflejada en la tabla Levofloxacinopresenta una alta actividad frente a Streptococcus pneumoniae, S.

El levofloxacino presenta una alta actividad frente aStreptococcuspneumoniae resistentes a penicilinas..

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No obstante,su actividad frente a estos microorganismos no supera la de lasantiguas quinolonas, y en el caso de Pseudomonas areuginosa la actividad del levofloxacinoes menor que la del ciprofloxacino El levofloxacinopresenta una escasa actividad frente a microorganismos anaerobios Levofloxacinorequiere un ajuste de dosis en el caso de insuficiencia renal.

El grupo piperazina libre ciprofloxacino parece tener mayor capacidad inhibitoria que elgrupo N-metilpiperazina levofloxacino Este efecto parece ser debidoa la capacidad que tienen todas las quinolonas de quelar elmagnesio y otros iones divalentes y trivalentes Se haobservado que la condrotoxicidad disminuye mucho si se administrajunto a las quinolonas suplementos de magnesio..

ISSN: Levofloxacin: a third-generation fluorquinolone. Descargar PDF.

Farmacia Hospitalaria

Juste Diez de Pinos a , M. Ribas Sala a.

Espectro quinolonas pdf to word

Hospital Cl?? No presenta reacciones adversas graves a diferencia del trovafloxacino y grepafloxacino ya retiradas del mercado. Palabras clave:.

Quinolonas - Definición

Levofloxacin is a third-generation fluorquinolone, commercially produced in Spain in The characteristics that differentiate levofloxacin from classical fluorquinolones are increased antibacterial spectrum against grampositive bacilli and slightly decreased activity against gramnegative bacilli. Due to the rapid absorption of the oral preparation, intravenous administration can be quickly substituted by oral administration.

Unlike trovafloxacin and grepafloxacin, which have been withdrawn from the market, it produces no serious adverse effects. The efficacy of levofloxacin for the clinical entities for which it is indicated has not been demonstrated to be greater than that of other drugs and consequently it is not a first-line drug.

Espectro quinolonas pdf to word

It should be kept as a reserve antibiotic to prevent the appearance of resistance and should be the second choice when resistant microorganisms or hypersensitivity to other drugs are present..

Texto completo. Barcelona: Masson, SA; Tillotson GS.

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Quinolones: estructure-activity relationships and future predictions. J Med Microbiol ; J Antimicrob Chemother ; The ehemistry and biological profile of trovafloxacin.. J Antimicrob Chemother, 39 , pp.

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Drug Safety ; J Antimicrob Chemother ; 26 Supl. D N Engl J Med ; Drugs ; J Biol Chem ; Biochem ; Mechanism of inhibition of DNA-gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA..

Biochem, 28 , pp. Mechanism of inhibition of DNA-gyrase by quinolone antibacterials: appearence of unique norfloxacin binding sites in enzyme DNA complexes..

Much more than documents.

J Biol Chem, , pp. Infection, 22 , pp. Antimicrob Agents Chemother ; Antimicrob Agents Chemother ; Lancet ; Comparative in vitro activity of levofloxacin and ofloxacin against grampositive bacteria. Diagn Microbiol Infect Dis ; J Antimicrob Chemother, 40 , pp. Ann Pharmacoter ; Clin Pharmacokinet ; Pharmacokinetics of grepafloxacin after oral administration of single and repeat dosis in healthy young males..

Clin Pharmacokinet, 33 , pp. Safety profile of grapefloxacin compared with other fluorquinolones..

Definición

J Toxicol Enviro Health ; Calcif Tissue Int ; Chem Pharmaceut Bull ; Clin Infect Dis ; Antimicrob Agents Chemother, 41 , pp. Respir Care ; New Orleans, Louisiana. A comparision of levofloxacin and ciprofloxacin for the treatment of complicated urinary tract infections.

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QUINOLONAS.pdf

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Espectro quinolonas pdf to word